Researchers from the Medical School at Wake Forestskogo University (USA) have identified a genetic mutation associated with hereditary kidney disease.
The mutation occurs in a gene that encodes a protein renin (angiotenzinogenaza) - a component of the renin-angiotensin system, regulating blood pressure.
Holders of such a genetic mutation in a child suffering from anemia and progressive renal disease, resulting in they have a vital need for hemodialysis. During this process the patient's blood passes through a filter (dialyzer), which removes waste substances from the blood, excess fluid and salt. To connect to «artificial kidney» patient implanted external shunt or impose subcutaneous fistula between the artery and vein.
If researchers can learn more about the impact of gene mutations in families with hereditary kidney disease, they will be able to understand how the renin acts in the body of healthy people. Already, researchers are aware that this protein plays an important role in maintaining normal blood pressure and preventing anemia in children.