Protein transfer colesteril-ester

Protein transfer colesteril-ester, coronary calcium and carotid artery intima-media thickness in a sample of middle-aged Japanese men
The relation between cholesteryl ester transfer protein (CETP) levels and atherosclerosis is controversial. Whether we examined the serum CETP levels were associated with subclinical atherosclerosis, independent of its most common gene variant in a sample of Japanese men. A population-based cross-sectional study of 250 Japanese men aged 40 to 49 years was conducted to Assess the intima-media thickness of the carotid artery, coronary artery calcium, serum CETP levels, and the CETP D442G gene variant. Compared with the lowest CETP quartile, the multivariate adjusted odds ratio for coronary artery calcium was 0.77 (95% confidence interval 0:18 to 3.36), 0.96 (95% confidence interval 0:27 to 3.40), and 3.49 (95% confidence interval 1:05 to 11.6) With increasing CETP quartiles. The serum CETP quartiles were also positively associated with the intima-media thickness of the carotid artery (adjusted mean 602, 616, 615, and 646 μm for the lowest quartile to top, respectively). The findings Remained unchanged after additional adjustment for the D442G CETP gene variant. No significant difference was found in the prevalence of coronary artery calcium or in the mean intima-media thickness of the carotid artery between participants with and without the D442G CETP gene variant.